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発表論文・総説 ( *corresponding author)

2023年

Tachiki, Y., *Suzuki, Y. II., Kurahashi, M., Ohki, K., Mavuk, O., Nakagawa, T., Ishihara, S., Gyoten, Y., Yamamoto, A. and *Imayoshi, I. (2023) Scale space calibrates present and subsequent spatial learning in Barnes maze in mice. eNeuro 10(6),

doi: 10.1523/ENEURO.0505-22.2023

*Nagasaki, S.C., Fukuda, T.D., Yamada, M., Suzuki, Y.I., Kakutani, R., Guy, A.T. and *Imayoshi, I. (2023) Enhancement of Vivid-based Photo-Activatable Gal4 Transcription Factor in Mammalian Cells. Cell Struct Funct. 48: 31–47. doi: 10.1247/csf.22074., doi: 10.1247/csf.22074.

Hayashi, M., Gullo, M., Senturk, G., Di Costanzo, S., Nagasaki, S.C., Kageyama, R., *Imayoshi, I. *Goulding, M., *Pfaff, S.L., *Gatto, G. A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements. bioRxiv, 2023, Mar 21:2023.03.21.533603. doi: 10.1101/2023.03.21.533603

2022年

Oishi, M., Stefan, P., Yamazaki, Y., Unekawa, M., Adachi, R., Yamada, M., Imayoshi, I., Abe, Y., Steinhäuser, C. and Tanaka K.F. (2022) Separate optogenetic manipulation of Nerve/glial antigen 2 (NG2) glia and mural cells using the NG2 promoter. Glia. doi: 10.1002/glia.24273.

Kaise, T., Fukui, M., Sueda, R., Piao W., Yamada, M., Kobayashi, T., Imayoshi, I. and Kageyama, R. (2022) Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity. Genes Dev. 36(1-2):23. doi: 10.1101/gad.349000.121.

2021年

Harada, Y., Yamada, M., Imayoshi, I., Kageyama, R., Suzuki, Y., Kuniya, T., Furutachi, S., Kawaguchi, D. and Gotoh Y. (2021) Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module. Nat Commun. 12(1):6562., doi: 10.1038/s41467-021-26605-0.

Inoue, Y.U., Morimoto, Y., Yamada, M., Kaneko, R., Shimaoka, K., Oki, S., Hotta, M., Asami, J., Koike, E., Hori, K., Hoshino, M., Imayoshi, I. and Inoue, T. (2021) An Optimized Preparation Method for Long ssDNA Donors to Facilitate Quick Knock-In Mouse Generation. Cells. 2021 10(5):1076., doi: 10.3390/cells10051076.

2020年

Yamada, M., Nagasaki, C.S., Suzuki, Y., Hirano, Y. and *Imayoshi, I. (2020) Optimization of light-inducible Gal4/UAS gene expression system in mammalian cells. iScience, 23, 101506, September 25, 2020. https://doi.org/10.1016/j.isci.2020.101506

*Imayoshi, I., Tabuchi, S., Matsumoto, M., Kitano, S., Miyachi, H., *Kageyama, R. and Yamanaka, A. (2020) Light-induced silencing of neural activity in Rosa26 knock-in and BAC transgenic mice conditionally expressing the microbial halorhodopsin eNpHR3. Sci Rep., 10(1):3191. doi: 10.1038/s41598-020-59984-3.

Seymour, P.A., Collin, C.A., Egeskov-Madsen, A.R., Jørgensen, M.C., Shimojo, H., Imayoshi, I., de Lichtenberg, K.H., Kopan, R., Kageyama, R. and Serup, P. (2020) Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Dev Cell. 52(6):731-747.e8, doi: 10.1016/j.devcel.2020.01.015.

Nguyen, R., Venkatesan, S., Binko, M., Yoon Bang, J., Cajanding, J.D., Briggs, C., Sargin, D., Imayoshi, I., Lambe, E.K. and Chul Kim, J. (2020) Cholecystokinin-expressing Interneurons of the Medial Prefrontal Cortex Mediate Working Memory Retrieval. J Neurosci. 40(11):2314-2331., doi: 10.1523/JNEUROSCI.1919-19.2020.

Yamada, M., Nagasaki, C.S., Ozawa, T. and *Imayoshi, I. (2020) Light-mediated control of gene expression in mammalian cells. Neurosci Res., 152:66-77. doi: 10.1016/j.neures.2019.12.018.

Okunomiya, T., Hioki, H., Nishimura, C., Yawata, S., Imayoshi, I., Kageyama, R., Takahashi, R. and Watanabe D. (2020) Generation of a MOR-CreER knock-in mouse line to study cells and neural circuits involved in mu opioid receptor signaling. Genesis, 58(1):e23341. doi: 10.1002/dvg.23341.

2019年

Kobayashi, T., Piao, W., Takamura, T., Kori, H., Miyachi, H., Kitano, S., Iwamoto, Y., Yamada, M., Imayoshi, I., Shioda, S., Ballabio, A. and Kageyama, R. (2019) Enhanced lysosomal degradation maintains the quiescent state of neural stem cells. Nat Commun., 10(1):5446. doi: 10.1038/s41467-019-13203-4.

*Imayoshi, I., Yamada, M. and Suzuki, Y. (2020) Regulatory Mechanism of Neural Progenitor Cells Revealed by Optical Manipulation of Gene Expressions.

In: Toyama Y., Miyawaki A., Nakamura M., Jinzaki M. (eds) Make Life Visible. Springer, Singapore

First Online 02 October 2019

DOI https://doi.org/10.1007/978-981-13-7908-6_2

Publisher Name Springer, Singapore

Print ISBN 978-981-13-7907-9

Online ISBN 978-981-13-7908-6

Tateya, T., Sakamoto, S., Ishidate, F., Hirashima, T., Imayoshi, I. and Kageyama R.(2019) Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea. Development, 146(21):dev177881. doi: 10.1242/dev.177881.

Chowdhury, S., Hung, C.J., Ozawa, S., Inutsuka, A., Kawamura, M., Kawashima, T., Bito, H., Imayoshi, I., Abe, M., Sakimura, K. and Yamanaka, A. (2019) Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice. eLife, 8, e44927.

Sueda, R., *Imayoshi, I. (equal contribution), Harima, Y. and *Kageyama, R. (2019) High Hes1 expression and resultant Ascl1 suppression regulate quiescent versus active neural stem cells in the adult mouse brain. Genes Dev, 33, 511-523. doi: 10.1101/gad.323196.118.

2018年

Yamada, M., Suzuki, Y., Nagasaki, C.S., Okuno, H. and *Imayoshi, I. (2018) Light-inducible Tet-gene expression system in mammalian cells. Cell Reports, 25, 487-500. [PDF] doi: 10.1016/j.celrep.2018.09.026.

Imanishi, A., Murat, T., Sato, M., Hotta, K., Imayoshi, I., Matsuda, M. and Terai, K. (2018) A novel morphological marker for the analysis of molecular activities at the single-cell level. Cell Struct Funct, 43, 129-140.

Perron, A., Nishikawa, Y., Iwata, J., Shimojo, H., Takaya, J., Kobayashi, K., Imayoshi, I., Mbenza, N.M., Takenoya, M., Kageyama, R., Kodama, Y. and Uesugi, M. (2018) Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem, 293, 8285-8294.

Li, W.L., Chu, M.W., Wu, A., Suzuki, Y., *Imayoshi, I. (co-corresponding) and *Komiyama T. (2018) Adult-born neurons facilitate olfactory bulb pattern separation during task engagement. eLife, 7, e33006.

Kaneko, R., Takatsuru, Y., Morita, A., Amano, I., Haijima, A., Imayoshi, I., Tamamaki, N., Koibuchi, N., Watanabe, M. and Yanagawa, Y. (2018) Inhibitory neuron-specific Cre-dependent red fluorescent labeling using VGAT BAC-based transgenic mouse lines with identified transgene integration sites. J Comp Neurol, 526, 373-396.

＊今吉　格、山田　真弓「生後脳・成体脳におけるニューロン新生と神経幹細胞の制御機構」、月刊「細胞」誌 2018/6月号

＊今吉　格、山田　真弓「遺伝子発現の光制御」、「Clinical Neuroscience」誌 36巻8号 2018年

＊今吉　格、鈴木　裕輔「遺伝子発現の光制御技術と神経幹細胞研究への応用」、「実験医学」誌 7月増刊号 2018年

2017年

*Suzuki, Y. and *Imayoshi, I. (2017) Network analysis of exploratory behaviors of mice in a spatial learning and memory task. PLoS One, 12, e0180789. [PDF]

＊今吉　格「神経幹細胞の増殖・分化の光制御と生後脳・成体脳ニューロン新生」、ブレインサイエンス・レビュー 2017　(株)クバプロ 2017年02月

ISBN: 978-4-87805-150-0

● 2017年以前の今吉の発表論文・総説等 (=> PubMed検索)

● Original article (Corresponding author)

Sakamoto, M., Ieki, N., Miyoshi, G., Mochimaru, D., Miyachi, H., Imura, T., Yamaguchi, M., Fishell, G., Mori, K., Kageyama, R. and Imayoshi, I.* (2014) Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning. The Journal of Neuroscience 34: 5788-5799.

Imayoshi, I.*, Isomura, A. (equal contribution), Harima, Y., Kawaguchi, K., Kori, H., Miyachi, H., Fujiwara, T.K., Ishidate, F. and Kageyama, R.* (2013) Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science (Research Article) 342: 1203-1208.

Imayoshi, I.*, Tabuchi, S., Hirano, K., Sakamoto, M., Kitano, S., Miyachi, H., Yamanaka, A and Kageyama, R. (2012) Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.0. Neuroscience Research 75: 53-58.

Imayoshi, I.*, Hirano, K., Kitano, S., MIyachi, H and Kageyama, R. (2012) In vivo evaluation of PhiC31 recombinase activity in transgenic mice. Neuroscience Research 73: 106-114.

Imayoshi, I.*, Hirano, K., Sakamoto, M., Miyoshi, G., Imura, T., Kitano, S., MIyachi, H and Kageyama, R. (2012) A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre- and Flp-mediated recombination. Neuroscience Research 73: 85-91.

● Original article (First author)

Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K. and Kageyama, R. (2010) Essential roles of Notch signaling in maintenance of neural stem cells in the developing and adult brains. The Journal of Neuroscience 30: 3489-3498.

Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S. and Kageyama, R. (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neuroscience 11: 1153-1161.

Imayoshi, I., Shimogori, T., Ohtsuka, T. and Kageyama, R. (2008) Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development 135: 2531-2541.

Imayoshi, I., Ohtsuka, T., Metzger, D., Chambon, P. and Kageyama R. (2006) Temporal regulation of Cre recombinase activity in neural stem cells. Genesis 44: 233-238.

Kita, A., Imayoshi, I. (equal contribution), Hojo, M., Kitagawa, M., Kokubu, H., Ohsawa, R., Ohtsuka, T., Kageyama, R. and Hashimoto, N. (2006) Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. Molecular Endocrinology 21: 1458-1466.

● Original article (Co-author)

Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K., Hirabayashi, Y. and Gotoh, Y. (2015) Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells. Nature Neuroscience 18: 657-665.

Tateya, T., Sakamoto, S., Imayoshi, I., Kageyama, R. (2015) In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium. Hear Res. 327: 209-217.

Ebina, T., Sohya, K., Imayoshi, I., Yin, S.T., Kimura, R., Yanagawa, Y., Kameda, H., Hioki, H., Kaneko, T., Tsumoto, T. (2014) 3D clustering of GABAergic neurons enhances inhibitory actions on excitatory neurons in the mouse visual cortex. Cell Reports 9: 1896-1907.

Tateya, T., Imayoshi, I., Tateya, I., Hamaguchi, K., Torii, H., Ito, J. and Kageyama, R. (2013) Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea. Development 140: 3848-3857.

Kitagawa, M., Hojo, M., Imayoshi, I., Goto, M., Ando, M., Ohtsuka, T., Kageyama, R., Miyamoto, S. (2013) Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development. Mech Dev. 130: 458-466.

Jacob, J., Kong, J., Moore, S., Milton, C., Sasai, N., Gonzalez-Quevedo, R., Terriente, J., Imayoshi, I., Kageyama, R., Wilkinson, D., Novitch B. and Briscoe, J. (2013) Retinoid signalling specifies distinct neuronal identities through graded expression of the transcription factor, Ascl1. Current Biology 23: 412-418.

Ninomiya, S., Esumi, S., Ohta, K., Fukuda, T., Ito, T., Imayoshi, I., Kageyama, R., Ikeda, T., Itohara, S. and Tamamaki, N. (2013) Amygdala kindling induces nestin expression in the leptomeninges of the neocortex.

Neuroscience Research 75: 121-129

Ueo, Y., Imayoshi, I., Kobayashi, T., Ohtsuka, T., Seno, H., Nakase, H., Chiba, T. and Kageyama, R. (2012) The role of Hes genes in intestinal development, homeostasis and tumor formation. Development 139: 1071-1082

Sakamoto, M., Imayoshi, I., Ohtsuka, T., Yamaguchi, M., Mori, K. and Kageyama, R. (2011)

Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. PNAS 108: 8479-8484

Tateya T., Imayoshi, I., Tateya, I., Ito J. and Kageyama R. (2011) Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Developmental Biology 352: 329-340

Kobayashi, T., Mizuno, H., Imayoshi, I., Furusawa, C., Shirahige K. and Kageyama. (2009) The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes & Development 23: 1870-1875

Kinameri, E., Inoue, T., Aruga, J., Imayoshi, I., Kageyama, R., Shimogori, T. and Moore, A. W. (2008) Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS ONE 3: e3859.

Forni, P. E., Scuoppo, C., Imayoshi, I., Taulli, T., Dastru, W., Sala, V., Betz, U. A. K., Muzzi, P., Martinuzzi, D., Vercelli, A. E., Kageyama, R. and Ponzetto, C. (2006) High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. The Journal of Neuroscience 26: 9593-9602.

Ohtsuka, T., Imayoshi, I., Shimojo, H., Nishi, E., Kageyama, R., and McConnel, S. K. (2006) Visualization of embryonic neural stem cells using Hes promoters in transgenic mice. Molecular and Cellular Neuroscience 31:109-122.

● Review (Corresponding author)

Imayoshi, I.* Ishidate, F. and Kageyama, R.* (2015) Real-time imaging of bHLH transcription factors reveals their dynamic control in multipotency and fate choice of neural stem cells. Frontiers in Cellular Neuroscience Aug 4;9:288.

Imayoshi, I.* and Kageyama, R.* (2014) Oscillatory control of bHLH factors in neural progenitors. Trends in Neurosciences 37: 531-538.

Sakamoto, M., Kageyama, R.* and Imayoshi, I.* (2014) The functional significance of newly born neurons integrated into olfactory bulb circuits. Frontiers in Neuroscience May 26; 8:121.

Imayoshi, I.* and Kageyama, R.* (2014) bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells. Neuron 82: 9-23.

Imayoshi, I.*, Shimojo, H. (equal contribution), Sakamoto, M., Ohtsuka, T. and Kageyama, R.* (2013) Genetic visualization of Notch signaling in mammalian neurogenesis. Cell Mol Life Sci. 70:2045-2057.

Imayoshi, I.*, Sakamoto, M. and Kageyama, R.* (2011) Genetic Methods to Identify and Manipulate Newly born Neurons in the Adult Brain. Frontiers in Neuroscience May 2;15:64.

Imayoshi, I*. and Kageyama, R.* (2011) The role of Notch signaling in adult neurogenesis. Molecular Neurobiology 44: 7-12.

Imayoshi, I.*, Sakamoto, M., Ohtsuka, T. and Kageyama, R. (2009) Continuous neurogenesis in the adult brain. Development, Growth & Differentiation 51: 379-386.

● Review (Co-author)

Harima Y, Imayoshi, I., Shimojo H, Kobayashi T, Kageyama R. (2014) The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes. Semin Cell Dev Biol. 34:85-90.

Kageyama, R., Shimojo, H. and Imayoshi, I. (2014) Dynamic expression and roles of Hes factors in neural development. Cell Tissue Res. 359:125-133.

Kageyama, R., Imayoshi, I., and Sakamoto, M. (2011) The role of neurogenesis in olfactory-dependent behaviors. Behavioral Brain Research 227:459-463.

Kageyama, R., Ohtsuka, T., Shimojo, H. and Imayoshi, I. (2008) Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nature Neuroscience 11: 1247-1251.

Kageyama, R., Ohtsuka, T., Shimojo, H. and Imayoshi, I. (2008) Dynamic regulation of Notch signaling in neural progenitor cells. Current Opinion in Cell Biology 21: 733-740.

● 日本語総説等

＊今吉　格 、鈴木裕輔「生後脳・成体脳ニューロン新生と嗅覚機能」、 AROMA RESEARCH誌 2016/8月号（vol.17/No.3）

＊今吉　格 「神経幹細胞の増殖・分化の光制御と生後脳・成体脳ニューロン新生」、ブレインサイエンス・レビュー 2017　2017年02月

＊今吉　格 「発生期および成体脳における神経幹細胞の制御メカニズム」、『生化学』誌、87(2), 245-248 (2015)

＊今吉　格「成体脳神経幹細胞の増殖と分化制御」、『医学のあゆみ』誌、251巻13号　2014年12月　

磯村彰宏、＊今吉　格「遺伝子発現の光制御とその応用の可能性」、『細胞工学』誌、2014年 3月号 Vol.33 No.3

＊今吉　格 「成体脳における神経幹細胞の光操作」、『現代科学』誌、2014年 11月号 No.524

＊今吉　格 「脳の設計図と変化する脳」、『分子精神医学』誌、第 14 巻　第 1 号　2014年 1 月

＊今吉　格 「生後脳・成体脳におけるニューロン新生」、『日本神経精神薬理学雑誌』誌、第 32 巻　第 5/6 号　2012 年 11 月

＊今吉　格、坂本　雅行、影山　龍一郎「成体脳ニューロン新生と高次脳機能」、『メディカルバイオ』誌、２００９年３月号特集「海馬ニューロンの新生-精神疾患と神経機能への関与」

＊今吉　格、坂本　雅行、影山　龍一郎「成体脳ニューロン新生の分子メカニズムと機能的意義」、

『実験医学』誌、２０１０年３月号増刊